Endocrine Abstracts

The benign prostatic hyperplasia (BPH) represents an enlargement of the epithelial and fibromuscular parts of the prostate. Although androgens per se do not cause BPH, an intact androgen metabolism is a prerequisite for the normal fetal and pubertal development of the prostate. Furthermore, growth factors play a role in the development of BPH. Animal experiments have shown that the prostate – similar to other organs of the reproductive tract – undergoes a neonatal st...

The recourse to the imagery by magnetic resonance brings to discover pathological images requiring an adapted exploration and therapeutic. The thickening of the pituitary stem can raise diagnostic difficulties. We report the case of 06 patients: 02 men and 04 women, average age is 31 years (04 years 1/2 at 48 years).The consultation is justified by an insipid diabetes in 05 cases, an amenorrhea - galactorrhea in a case. The hormonal assessment revealed a...

Male- or female-like neural control of gonadal function and reproductive behaviour is determined by sex-specific activation of estrogen receptors (ER) in the developing brain during a limited, critical period during ontogenesis. Exposure of the neonatal female brain to inappropriately high estrogen concentrations results in irreversible defeminization of neuroendocrine function which is manifested by disturbed cyclic ovarian activity and decreased female sexual receptivity in ...

Glucocorticoid hormones play a key role in glucose, fat and protein metabolism and dampen immune and inflammatory reactions. Synthetic equivalents are widely used as therapeutic drugs. Upon hormone binding, the glucocorticoid receptor (GR) detaches from a cytoplasmic multiprotein complex, translocates to the nucleus and regulates the transcription of target genes either directly or indirectly through interference with other transcription regulators.While...

The efficacy of Levothyroxine suppressive therapy in thyroid nodules is still controversial; the aim of this study is to evaluate the effect of levothyroxine on nodule volume.Subjects and methods: Ninety three euthyroid patients (92 females, mean age =43.7 years) harboring multindular (n=53) or solitary (n=40) nodules hare been treated for at least 6 months with thyroid hormones (Levothyroxine), the nodule size is assessed by it’s maxi...

Aims: To evaluate the cardiovascular morbidity in patients with and without hypothyroidism admitted to a central hospital, between 1989 and 2004.Materials and methods: Data from the Hospital Coding Centre were retrospectively analysed according to International Classification of Diseases (9th version) criteria. We have studied the distribution by age, sex, causes and duration of admissions. Statistical analysis was performed with Student’s t-test, &...

Thyroid carcinoma is collectively the most common of the endocrine cancers and overall has a good prognosis if diagnosed early. However, the molecular events underlying development of the two most common types, follicular (FTC) and papillary thyroid carcinoma (PTC), is not well understood. Furthermore, pre-operative distinction between FTC and benign follicular adenomas (FA) by fine-needle aspiration remains a challenge. Microarray expression analysis is a powerful tool that m...

A 60 year old pest control worker presented to the dermatologists with a 3-month history of progressive thickening and change in texture of skin lesions affecting the face, lips and eyelids. Histology revealed papular mucinosis/lichen myxoedematosus and he was treated with plasma exchange, high dose steroids and cyclophosphamide. Investigations for associated tiredness, four months following presentation and initiation of therapy revealed impaired GH and cortisol responses to ...

Objective: To improve post-operative thyroid surgery practice and to determine if it would be safe to perform thyroid surgery as day surgery. To identify the nature and timings of acute life threatening airway complications, trends in current practice, and gain information on perioperative mortality....

Vascular calcification is a regulated process with similarities to osteogenesis, however, the precise mechanism underlying this process is poorly understood. Pericytes are pluripotential microvascular cells which have been shown to differentiate along an osteogenic lineage. Glucocorticoids are widely prescribed drugs but have adverse side-effects including both vascular lesion formation and bone loss. The mechanism underpinning the contrasting effects of dexamethasone (dex) on...